A bunch of pages

This commit is contained in:
Aleks Rūtiņš 2024-06-02 12:44:27 -04:00
parent 33555e975c
commit b3b84d42d4
10 changed files with 136 additions and 7 deletions

View file

@ -4,4 +4,35 @@
# Activators
<nav-links back="/repressors.html" next="/hill-functions.html"></nav-links>
Just like repressors can inhibit a gene, **activators** can enable it. Just like repressors, activators' behavior can also be changed by small molecule inputs. Another example from our bacterial friends is the LuxR activator, which only acts as an activator in the presence of the compound ligand.
Here's a diagram, with the activator labeled A:
![A diagram of a gene with and without an activator.](/assets/activator-dg.png)
<i class="cite">Credit: CalTech</i>
For activators, we have a different curve (seen below in red, contrasted to the repressor curve in blue):
$$\beta(a)=\beta_0\frac{p_\text{bound}}{p_\text{tot}}=\beta_0\frac{a/K_d}{1 + a/K_d}$$
<div class="graph">
<div id="binding-curve"></div>
<div>
<label for="kd">K<sub>d</sub</label>
<input type="range" id="kd" value=1>
</div>
<div>
<label for="beta0">β<sub>0</sub></label>
<input type="range" id="beta0" value=1>
</div>
</div>
As you can see, an activator has exactly the opposite effect as a repressor.
That was a short section. Onward!
<nav-links back="/repressors.html" next="/hill-functions.html"></nav-links>
<script>
plot('#binding-curve', (kd, beta0) => [`${beta0}/(1 + x/(${kd}))`, `${beta0} * ((x/${kd})/(1 + (x/${kd})))`], ['#kd', '#beta0'], [[0, 10], [0, 10]])
</script>